Isoflavanones from Desmodium oxyphyllum and their cytotoxicity |
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| Authors: | Yan-Ping Li Yin-Ke Li Gang Du Hai-Yin Yang Xue-Mei Gao |
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| Institution: | 1. School of Pharmacy, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China;2. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission &3. Ministry of Education, Yunnan University of Nationalities, Kunming 650500, China |
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| Abstract: | Two new isoflavanones, (3R)-7-hydroxy-4′-methoxy-5-methoxycarbonyl-isoflavanone (1) and (3R)-8-hydroxy-4′-methoxy-7-methoxycarbonyl-isoflavanone (2), together with seven known isoflavanones (3–9) were isolated from Desmodium oxyphyllum of the Leguminosae family. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compound 1 showed good cytotoxicity against NB4 and SHSY5Y cell lines with IC50 values of 3.1 and 2.5 μM; compound 2 exhibited cytotoxicity against PC3 cell lines with a IC50 value of 3.6 μM; compound 4 showed cytotoxicity against A549 and SHSY5Y cell lines with IC50 values of 3.6 and 2.8 μM; and compound 5 displayed cytotoxicity against NB4, SHSY5Y, and MCF7 cell lines with IC50 values of 2.6, 3.8, and 2.8 μM, respectively. Other compounds also showed moderate cytotoxicity for some tested cell lines with IC50 values between 5.4 and 8.8 μM. |
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| Keywords: | Desmodium oxyphyllum isoflavanone cytotoxicity |
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