Chemical constituents from Euphorbia wallichii and their biological activities |
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| Authors: | Da-Song Yang Wei-Bing Peng Yong-Ping Yang Ke-Chun Liu |
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| Affiliation: | 1. Key Laboratory of Economic Plants and Biotechnology, Germplasm Bank of Wild Species in Southwest China, Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;2. Biology Institute of Shandong Academy of Sciences, Jinan 250014, China |
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| Abstract: | One rare diterpenoid which was an unusual phorbol derivative possessing a 5-ene-7-oxo functional group, wallichiioid A (1), and 17 known compounds (2–18) were isolated from the aerial parts of Euphorbia wallichii. The structures and relative configuration of these compounds were elucidated on the basis of extensive spectroscopic interpretation. All the known compounds were isolated from E. wallichii for the first time. Diterpenoids 1–5 were tested for their cytotoxicity against five cancer cell lines (A-549, MCF-7, Hep G2, HeLa, and P388) and showed IC50 values in the range of 8.19–29.72 μg/mL. The antiangiogenic activities of diterpenoids 1–5 were also evaluated using a zebrafish model. |
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| Keywords: | Euphorbia wallichii diterpenoid wallichiioid A cytotoxicity antiangiogenic activities |
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