Cameroonemide A: a new ceramide from Helichrysum cameroonense |
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| Authors: | Kakam Zanetsie Antoine Etienne Dongo Simeon F Kouam Barbara Schulz Karsten Krohn |
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| Institution: | 1. Department of Organic Chemistry, Faculty of Science , University of Yaounde I , P.O. Box 812, Yaounde, Cameroon;2. Department of Chemistry, Higher Teachers' Training College , University of Yaounde I , Yaounde, BP 47, Cameroon;3. Institute of Microbiology, Technical University of Braunschweig , Braunschweig, D-38106, Germany;4. Department of Chemistry , University of Paderborn , Warburger Stra?e 100, 33098, Paderborn, Germany |
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| Abstract: | From the extracts of all parts of the plant Helichrysum cameroonense, five compounds were isolated and identified. One of them, a ceramide, named cameroonemide A (1), is reported for the first time as a new natural product. Its structure was determined by comprehensive analyses of their 1D and 2D NMR and HR-EI-MS spectral data. The remaining four known compounds were identified by comparing their spectroscopic data with those reported in the literature as kaurenoic acid (2), 3-acetyloxykaurenoic acid (3), β-sitosterol (4), and β-sitosterol glucopyranoside (5). Preliminary studies showed that 3-acetyloxykaurenoic acid (3) inhibited the alga Chlorella fusca, while kaurenoic acid (2) showed strong antibacterial activity against Bacillus megaterium. |
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| Keywords: | Helichrysum cameroonense Asteraceae ceramide antimicrobial activity |
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