A New Sesquiterpene Lactone from Tsoongiodendron Odorum Chun |
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| Authors: | Xiao-Kai Song Peng-Fei Tu Li-Jun Wu Yang Cai Hui Zhu Yang Lu |
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| Affiliation: | 1. Shenyang Pharmaceutical University , 103 Wenhua Road, Shengyang, 110015, China;2. School of Pharmaceutical Sciences, Peking University , 38 Xueyuan Road, Beijing, 100083, China;3. Institute of Materia Medica, Chinese Academy of Medical Sciences , Beijing, 100050, China |
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| Abstract: | Abstract A new sesquiterpene lactone (1) was obtained from the cytotoxic fraction of 95% ethanol extract of root barks of Tsoongiodendron odorum Chun together with two known sesquiterpene lactones, costunolide (2) and parthenolide (3). The structure of 1 was elucidated as 5α, 6α, 7β, 10β-11α, 13-dihydro-4(15)-eudesmene-12, 6-olide on the basis of chemical and spectral evidence including X-ray diffraction analysis. Costunolide showed cytotoxic activity against human leukemia (HL-60) cell line. Parthenolide showed promising cytotoxic activities in vitro against HCT-8, Bel-7402, SKOV3, KB, HELA and EJ cell lines. Also, the cytotoxic ethyl acetate fraction of ethanol extract of the root barks from which three chemical components were isolated showed promising cytotoxic activities in vitro against KB, BGC-823, Bel-7402, HCT-8, HL-60 cell lines. |
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| Keywords: | Tsoongiodendron odorum Chun Sesquiterpene lactones Cytotoxic activity |
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