Total synthesis and cytotoxicity evaluation of syrinenin-4-O-farnesylether and its analogues |
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| Authors: | Hong-Bin Zou Jing-Xu Gong Hai-Bo Li Lei-Xiang Yang Li-Hong Hu Chang-Xin Zhou |
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| Institution: | College of Pharmaceutical Sciences, Zhejiang University, Department of Traditional Chinese Medicine and Natural Drug Research , Hangzhou, 310031, China |
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| Abstract: | First synthesis of natural product, syrinenin-4-O-farnesylether (1), was carried out via two different paths. Four of its derivatives (9–12) were also prepared. Cytotoxicity screening of the selected compounds were performed on six tumour cell lines. Compound 12 exhibited prominent IC50 values of 1.9 μM and 0.8 μM on CNE and PC-3 cells, respectively. |
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| Keywords: | Syrinenin derivative Syrinenin-4-O-farnesylether Biological activity Cytotoxicity |
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