Two new cytotoxic ent-clerodane diterpenoids from Scutellaria barbata |
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| Authors: | Gui-Wu Qu Xi-Dian Yue Gui-Sheng Li Qun-Ying Yu |
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| Institution: | 1. College of Food Science and Technology, Ocean University of China , Qingdao, 266003, China;2. School of Pharmaceutical Science, Yantai University , Yantai, 264005, China |
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| Abstract: | Two new ent-clerodane diterpenoids have been isolated from Scutellaria barbata, and their structures were established by detailed spectroscopic analyses as (13R)-6α,7β-dihydroxy-8β,13-epoxy-11β-nicotinyloxy-ent-clerodan-3-en-15,16-olide (scutelinquanine D, 1) and (11E)-6α-acetoxy-7β,8β-dihydroxy-ent-clerodan-3,11,13-trien-15,16-olide (6-acetoxybarbatin C, 2). In vitro, the isolated two new compounds showed significant cytotoxic activities against three human cancer cell lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells), and gave IC50 values in the range of 2.5–6.6 μM. |
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| Keywords: | Scutellaria barbata ent-clerodane diterpenoid scutelinquanine D 6-acetoxybarbatin C cytotoxic activity |
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