A new elemanolide sesquiterpene lactone from Elephantopus scaber |
| |
| Authors: | Qiao-Li Liang Zhi-Da Min Yu-Ping Tang |
| |
| Affiliation: | 1. Department of Medicinal Chemistry , Nanjing University of Chinese Medicine , Nanjing, 210046, China liangqiaoli@sohu.com;3. Department of Natural Medicine Chemistry , China Pharmaceutical University , Nanjing, 210038, China;4. Jiangsu Key Laboratory for TCM Formulae Research , Nanjing University of Chinese Medicine , Nanjing, 210046, China |
| |
| Abstract: | A new elemanolide sesquiterpene lactone, named elescaberin (1), together with two known compounds, namely, isodeoxyelephantopin (2) and deoxyelephantopin (3), was isolated from the whole plant of Elephantopus scaber. The structure of 1 was elucidated on the basis of spectroscopic analysis. All three compounds exhibited significant inhibitory activities against human SMMC-7721 liver cancer cells in vitro (IC50 8.18–14.08 μmol/l). |
| |
| Keywords: | Elephantopus scaber Compositae sesquiterpene lactone anticancer elescaberin |
|
|
