Cytotoxic monacolin analogs from Monascus purpureus-fermented rice |
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| Authors: | Ming-Tao Liu A-Li Wang Zhen Sun Jin-Jie Li Xiu-Li Wu Yan-Xia Liu |
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| Affiliation: | 1. SRI International , Menlo Park , CA , 94025 , USA;2. Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University , Beijing , 100191 , China;3. College of Pharmacy, Ningxia Pharmaceutical University , Yinchuan , 750004 , China |
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| Abstract: | Two new monacolin analogs, monacolins O (1) and P (2), along with three known analogs, have been isolated from the ethanolic extract of Monascus purpureus-fermented rice. Their structures and absolute configurations were elucidated by spectroscopic methods, especially 2D NMR and CD spectral analyses as well as chemical method. Both 1 and 2 were tested against five tumor cell lines, and compound 1 exhibited selective cytotoxic activity against A2780 and A549 cell lines, with IC50 values of 3.7 and 8.0 μM, respectively. |
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| Keywords: | Monascus purpureus-fermented rice monacolin analogs absolute configuration NMR CD cytotoxic activity |
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