Lignans from the stems of Sambucus williamsii and their effects on osteoblastic UMR106 cells |
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Authors: | Xu-Juan Yang Man-Sau Wong Nai-Li Wang Sun-Chi Chan |
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Institution: | 1. Shenyang Pharmaceutical University , 110015, China;2. State Key laboratory of Chinese Medicine and Molecular Pharmacology , 518055, China;3. Hong Kong Polytechnic University , China;4. Graduate School at Shenzhen, Tsinghua University , 518055, China |
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Abstract: | Three new lignans, sambucunol A (8) ((+)-erythro-1-(4-hydroxy-3-methoxyphenyl)-2-4-(4-hydroxy-3-methoxycinnamoyloxypropanyl)-2-hydroxyphenoxy]-1, 3-propanediol), sambucunol B (9) ((+)-threo-1-(4-hydroxyl-3-methoxyphenyl)-2-4-(4-hydroxy-3-methoxy-cinnamoyloxy propanyl)-2-hydroxyphenoxy]-1, 3-propanediol) and buddlenol G (10) (2-{4-2, 3-dihydro-3-hydroxymethyl-7-hydroxy-5-(4-hydroxy-3-methoxycinnamoyloxypropanyl)-2-benzofuranyl]-2,6-dimethoxyphenoxy}-1-(4- hydroxy-3-methoxyphenyl) -1, 3-propanediol), along with seven known ones, including ( ? )-syringaresinol (1), ( ? )-pinoresinol (2), 1, 2-bis(4-hydroxy-3-methoxy phenyl)-1, 3-propanediol (3), ( ? )-erythro-1-(4-hydroxy-3-methoxyphenyl)-2-4-(3-hydroxy propanyl)-2-methoxyphenoxy]-1, 3-propanediol (4), ( ? )-threo-1-(4-hydroxy-3-methoxyphenyl)-2-4-(3-hydroxypropanyl)-2-methoxy phenoxy]-1, 3-propanediol (5), ( ? )-lariciresinol (6) and ( ? )-dihydrodehydrodiconiferyl alcohol (7), were isolated from the 60% ethanol extract of stems of Sambucus williamsii Hance by chromatographic methods. Their structures were established by spectral analysis. The effects of isolated compounds on the osteoblast-like UMR106 cell proliferation and ALP activities were determined. Compounds 2, 7 and 10 showed stimulating effects both on UMR106 cell proliferation and ALP activity. Compounds 1, 3, 6 and 8 stimulated UMR106 cell proliferation, while compounds 4 and 5 induced ALP activity in UMR106 cell. |
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Keywords: | Sambucus williamsii Caprifoliaceae Lignans UMR106 cell Proliferation ALP activity |
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