Two new triterpenoid saponins from Ilex cornuta |
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| Authors: | Ming-Lei Wang Yan-Li Liu Yun-Qiu Li Shi-Lin Yang |
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| Institution: | 1. College of Pharmaceutical Science, Soochow University, Suzhou 215123, China;2. College of Pharmacy, Guilin Medical University, Guilin 541004, China;3. College of Pharmacy, Guilin Medical University, Guilin 541004, China |
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| Abstract: | Two new triterpenoid saponins (1 and 2) were isolated from the stems of Ilex cornuta, along with two known triterpenoids (3 and 4). The structures of compounds 1 and 2 were determined as ursane-12,19-diene-28-oic acid 3β-O-β-d-glucuronopyranoside-6-O-methyl ester (1), 3α,23α-dihydroxy-olean-9(11),12-diene-28-oic acid 28-O-β-d-glucopyranosyl ester (2), on the basis of hydrolysis and spectral evidence, including 1D and 2D NMR and high resolution electrospray ionization mass spectrometry (HR-ESI-MS) analyses. Protective effects of compounds 1–4 were tested against H2O2-induced H9c2 cardiomyocyte injury, and the data showed that all these compounds had no cell-protective effect. |
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| Keywords: | Ilex cornuta Aquifoliaceae ursane-12 d-glucuronopyranoside-6-O-methyl ester" target="_blank">19-diene-28-oic acid 3β-O-β-d-glucuronopyranoside-6-O-methyl ester 3α 23α-dihydroxy-olean-9(11) d-glucopyranosyl ester" target="_blank">12-diene-28-oic acid 28-O-β-d-glucopyranosyl ester cardiomyocyte oxidative injury cell-protective effect |
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