Flavans from the leaf of Ilex centrochinensis |
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| Authors: | Lu-Jun Li Yue Zhang Hui-Fang Pi Han-Li Ruan Ji-Zhou Wu |
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| Affiliation: | 1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology , Wuhan, 430030, China;2. Hubei Key Laboratory of Bio-Technology of Traditional Chinese Medicine, Hubei University , Wuhan, 430062, China;3. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology , Wuhan, 430030, China |
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| Abstract: | Phytochemical investigation of the leaf of Ilex centrochinensis led to the isolation and characterization of four flavans, one flavanone (5), and one flavone (6), including a new compound whose structure was elucidated as (2S)-5,3′,4′-trihydroxy-7-methoxyflavan (1) and a new natural product whose structure was elucidated as (2S)-5-hydroxy-7,3′,4′-trimethoxyflavan (4) on the basis of spectroscopic methods especially 1D and 2D NMR, CD, and mass spectral analyses. Compounds 1 and 4 exhibited weak cytotoxic activity against Huh7 cell line and no cytotoxic activity against Caco-2 cell line. |
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| Keywords: | Ilex centrochinensis (2S)-5,3′,4′-trihydroxy-7-methoxyflavan (2S)-5-hydroxy-7,3′,4′-trimethoxyflavan cytotoxic activity |
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