Movement disorders in the Hfe knockout mouse |
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| Authors: | Mari S Golub Stacey L Germann Renee S Araiza J Rachel Reader Stephen M Griffey K C Kent Lloyd |
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| Institution: | Mutant Mouse Regional Resource Center (MMRRC) University of California, Murine Behavior Assessment Laboratory (MSG, SLG), Murine Targeted Genomics Laboratory (RSA, KCKL), Comparative Pathology Laboratory (SMG, JRR), Davis Davis, California, 95616, USA |
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| Abstract: | AbstractThe Hfe( - / - ) mouse is a model for human hereditary hemochromatosis (HHH). The accumulation of tissue iron in this condition has led to the suggestion that HHH patients may be at higher risk for neurodegenerative diseases. In this study, adult male Hfe( - / - ) mice and wildtype controls ( n = 12/group) were evaluated for impairment with motor tests (stride length, landing footsplay, rotarod) as well as a general observational battery (Functional Observational Battery, FOB). Hfe( - / - ) mice were characterized by more falls from the rotarod, wider forelimb landing footsplay and hypersensitivity to proximal stimulation. Iron accumulation in brain was not detected by histopathology. These data suggest that a motor syndrome may be associated with HHH that could be further understood through the Hfe( - / - ) mouse model. |
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| Keywords: | Hemochromatosis iron motor behavior transgenic mouse Parkinson's disease |
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