Two new casbane diterpenoids from the roots of Euphorbia pekinensis |
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| Authors: | Feng-Guang Shao Ren Bu Cui Zhang Chao-Jun Chen Jian Huang |
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| Institution: | 1. School of Traditional Chinese Materia Medica 49#, Shenyang Pharmaceutical University , Shenyang, 110016, China;2. School of Pharmacy, Inner Mongolia Medical College , Hohhot, 010110, China;3. School of Pharmacy, Inner Mongolia Medical College , Hohhot, 010110, China;4. School of Traditional Chinese Materia Medica 49#, Shenyang Pharmaceutical University , Shenyang, 110016, China;5. Key Laboratory of Structure-Based Drug Design &6. Discovery of Ministry of Education, Shenyang Pharmaceutical University , Shenyang, 110016, China |
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| Abstract: | From the roots of Euphorbia pekinensis, two new casbane diterpenoids, named pekinenins A (1) and B (2), were isolated. Their structures were elucidated as 18-hydroxy-1βH,2αH-casba-3E,7E,11E-trien-5-one (1), 5α-methoxy-1βH,2αH-casba-3Z,7E,11E-trien-18-oic acid (2) by a combination of 1D and 2D NMR spectroscopy and mass spectrometry. In the cytotoxicity assay of the two new compounds against Hela, MCF-7, and C6 human cancer cell lines, compound 1 showed moderate cytotoxic activity against two human cancer cell lines, Hela and C6, with IC50 values of 42.97 and 50.00 μM, respectively. |
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| Keywords: | Euphorbia pekinensis Rupr pekinenin A pekinenin B casbane diterpenoids |
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