Biotransformation on the triterpenoid saponin of Ardisia gigantifolia by Aspergillus avenaceus AS 3.4454 |
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| Authors: | Li-Hua Mu Yong-Jie Gu Li-Hua Wang Bai-Ping Ma Li Lu |
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| Affiliation: | 1. Department of Clinical Pharmacology, General Hospital of PLA, Beijing 100853, China;2. Hebei North University, Zhangjiakou 075000, China;3. Beijing Institute of Radiation Medicine, Beijing 100850, China |
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| Abstract: | Compound 1, a triterpenoid saponin from Ardisia gigantifolia Stapf. showing potential anti-tumor activity, was transformed into three derivatives (2–4) by Aspergillus avenaceus 3.4454. Among them, compounds 2 and 3 are new compounds. Their structures were elucidated on the basis of 1D NMR, 2D NMR, HR-ESI-MS, and optical rotation data. Compounds 1–3 were evaluated for their cytotoxicity against human hepatocellular carcinoma and normal liver cells by cell counting kit 8 colorimetric assay. Compound 3 displayed better cytotoxicity against Bel-7402 and HepG2 cell lines and much weaker cytotoxicity against normal liver L02 cell than that of positive control (epirubicin hydrochloride). |
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| Keywords: | biotransformation triterpenoid saponin Ardisia gigantifolia Aspergillus avenaceus |
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