A new ganoderic acid from Ganoderma lucidum mycelia |
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| Authors: | Jia-Le Wang Ying-Bo Li Ru-Ming Liu |
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| Affiliation: | 1. Key Laboratory of Microbial Metabolism , Ministry of Education, School of Life Sciences &2. Biotechnology, Shanghai Jiao Tong University , Shanghai, 200240, China;3. State Key Laboratory of Bioreactor Engineering , East China University of Science and Technology , Shanghai, 200237, China |
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| Abstract: | A new ganoderic acid (GA), 7-O-ethyl ganoderic acid O (GA-O) (1), together with two known compounds, GA-T (2) and GA-Me (3), was isolated and purified from fermented mycelia of Ganoderma lucidum. The structure of the new triterpenoid was elucidated on the basis of the interpretation of extensive spectroscopic data (HR-MS, IR, UV, 1D and 2D NMR) as 3α,15α,22-triacetoxy-7α-ethoxy-5α-lanost-8,24E-dien-26-oic acid. The new compound was found to contain a rare ethoxyl group at C-7. In addition, its cytotoxicity against 95D and HeLa human cancer cell lines was also evaluated. |
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| Keywords: | Ganoderma lucidum Ganodermataceae 7-O-ethyl GA-O ethoxyl cytotoxicity |
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