The caffeoyl phenylethanoid glycosides from Lindernia ruellioides and their anti-HBV effects |
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| Authors: | Jing-Chen Wei Peng-Cheng Wang Xian-Li Zhou Kun Tang Qin Luo Qin Xu |
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| Affiliation: | 1. College of Pharmacy, Guilin Medical University, Guilin 541004, China;2. Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair, Guilin Medical University, Guilin 541001, China;3. Department of Pharmacy, Affiliated Hospital of Guilin Medical University, Guilin 541004, China |
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| Abstract: | AbstractFive caffeoyl phenylethanoid glycosides, including two new ones linderruelliosides A (1) and B (2), were isolated from the leaves and stems of Lindernia ruellioides. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR and MS spectra. In addition, all these compounds were tested for their anti-HBV activity. Compounds 1, 3, and 4 showed anti-HBV activities, with IC50 values of 54.87, 30.74, and 69.02 μM for HBsAg and 26.70, 5.17, and 7.08 μM for HBeAg, respectively. |
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| Keywords: | Scrophulariaceae Lindernia ruellioides caffeoyl phenylethanoid glycoside anti-HBV |
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