首页 | 本学科首页   官方微博 | 高级检索  
     


New furostanol glycosides from the rhizomes of Dioscorea futschauensis R. Kunth
Authors:Hong-Wei Liu  San-Long Wang  Bin Cai  Ge-Xia Qu  Xu-Juan Yang  Hisayoshi Kobayashi
Affiliation:1. Department of Natural Products Chemistry , Shenyang Pharmaceutical University , Wenhua-Road 103, 110016, Shenyang, China;2. Laboratory of Bioactive Assay , Tianjin Institute of Biomedicine , 300384, Tianjin, China;3. Institute of Molecular and Cellular Biosciences, The University of Tokyo , 113-0032, Tokyo, Japan
Abstract:Two new furostanol glycosides, 26-O-β-D-glucopyranosyl-3β,26-dihydroxy-23(S)-methoxyl-25(R)-furosta-5,20(22)-dien-3-O-α-L-rhamnopyranosyl(1→2)-[β-D-glucopyranosyl(1→3)]-β-D-glucopyranoside (dioscoreside E, 1) and 26-O-β-D-glucopyranosyl-3β,26-dihydroxy-25(R)-furosta-5,20(22)-dien-3-O-α-L-rhamnopyranosyl(1→2)-[β-D-glucopyranosyl (1→3)]-β-D-glucopyranoside (prtotogracillin, 2), together with 11 known furostanol glycosides were isolated from the rhizomes of Dioscorea futshauensis R. Kunth. Their structures were elucidated on the basis of spectroscopic analysis (NMR and FABMS). Their anti-fungal activity against the plant pathogenic fungus Pyricularia oryzae and cytotoxic activity on K562 cancer cell line were evaluated in vitro.
Keywords:Furostanol glycosides  Anti-fungal  Cytotoxic
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号