New furostanol glycosides from the rhizomes of Dioscorea futschauensis R. Kunth |
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| Authors: | Hong-Wei Liu San-Long Wang Bin Cai Ge-Xia Qu Xu-Juan Yang Hisayoshi Kobayashi |
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| Affiliation: | 1. Department of Natural Products Chemistry , Shenyang Pharmaceutical University , Wenhua-Road 103, 110016, Shenyang, China;2. Laboratory of Bioactive Assay , Tianjin Institute of Biomedicine , 300384, Tianjin, China;3. Institute of Molecular and Cellular Biosciences, The University of Tokyo , 113-0032, Tokyo, Japan |
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| Abstract: | Two new furostanol glycosides, 26-O-β-D-glucopyranosyl-3β,26-dihydroxy-23(S)-methoxyl-25(R)-furosta-5,20(22)-dien-3-O-α-L-rhamnopyranosyl(1→2)-[β-D-glucopyranosyl(1→3)]-β-D-glucopyranoside (dioscoreside E, 1) and 26-O-β-D-glucopyranosyl-3β,26-dihydroxy-25(R)-furosta-5,20(22)-dien-3-O-α-L-rhamnopyranosyl(1→2)-[β-D-glucopyranosyl (1→3)]-β-D-glucopyranoside (prtotogracillin, 2), together with 11 known furostanol glycosides were isolated from the rhizomes of Dioscorea futshauensis R. Kunth. Their structures were elucidated on the basis of spectroscopic analysis (NMR and FABMS). Their anti-fungal activity against the plant pathogenic fungus Pyricularia oryzae and cytotoxic activity on K562 cancer cell line were evaluated in vitro. |
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| Keywords: | Furostanol glycosides Anti-fungal Cytotoxic |
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