Adlumiceine methyl ester,a new alkaloid from Fumaria vaillantii |
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| Authors: | Milad Iranshahy Hamideh Javidi-Shirazi Ngoc B Pham Ronald J Quinn Hamid Sadeghian |
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| Institution: | 1. Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;2. Eskitis Institute, Griffith University, Brisbane, QLD4111, Australia;3. Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran;4. Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran |
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| Abstract: | A new alkaloid, adlumiceine methyl ester (1), together with two known alkaloids, parfumine (2) and N-methylhydrastine methyl ester (3), was isolated from aerial parts of Fumaria vaillantii. The structures of compounds were determined by 1D/2D NMR and MS data. All three compounds were tested for cytotoxic activity against PC3 and MCF7 cell lines using Alamar blue assay. The tested compounds showed no significant cytotoxic activity (IC50>50 μM) against PC3 and MCF7 cell lines. |
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| Keywords: | Fumaria Papaveraceae alkaloids parfumine N-methylhydrastine methyl ester |
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