Combining ECT with pharmacological treatment of depressed inpatients in a naturalistic study is not associated with serum BDNF level increase |
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| Affiliation: | 1. Programa de Pós-Graduacão em Ciências Médicas: Psiquiatria, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;2. Departamento de Psiquiatria e Medicina Legal, Hospital de Clínicas de Porto Alegre, Brazil;1. School of Medicine, Department of Family Medicine, University of Pittsburgh, Pittsburgh;2. School of Medicine, Department of Family Medicine, University of Pittsburgh, Pittsburgh, PA;3. School of Medicine, Department of Family Medicine, University of Pittsburgh, Pittsburgh, PA;4. Department of Health Policy and Management, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA;5. School of Medicine, Department of Family Medicine, University of Pittsburgh, Pittsburgh, PA;1. Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Bradley Hospital, 1011 Veterans Memorial Parkway, East Providence, RI 02915, United States;2. Department of Psychology, Harvard University, 33 Kirkland St, Cambridge, MA 02138, United States;1. Israel Center for Disease Control (ICDC), Israel Ministry of Health, Ramat Gan, Israel;2. Department of Epidemiology and Preventive Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;1. Department of Medicine, Duke University Medical Center, Durham, NC, United States;2. Duke Molecular Physiology Institute, Durham, NC, United States;3. Duke Center for Human Disease Modeling, Durham, NC, United States;4. Durham Veterans Affairs Medical Center, Durham, NC, United States;5. The VA Mid-Atlantic Mental Illness Research, Education, and Clinical Center, Durham, NC, United States;6. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States;1. Ahmanson-Lovelace Brain Mapping Center, Department of Neurology, University of California Los Angeles, 635 Charles E Young Drive S #225, Los Angeles, CA, 90095, USA;2. Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 200 UCLA Medical Plaza #265, Los Angeles, CA, 90095, USA;1. Sunnybrook Research Institute, Toronto, ON, Canada;2. Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada;3. Division of Orthopaedic Surgery, University of Toronto, ON, Canada |
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| Abstract: | BackgroundBDNF blood levels are reduced in MDD. They can be increased with pharmacologic treatment and ECT, but it is not clear whether the combination of treatments promotes an additional increase. The present study aims to evaluate whether combined treatment promotes an increase in BDNF, restoring the level to that of non-depressed controls.MethodsNinety-nine adult inpatients were invited to participate in this naturalistic prospective cohort study between May 2011 and April 2013. Diagnosis was made by MINI, and the symptoms were evaluated at admission and at discharge by HDRS-17. Those inpatients with a diagnosis of depression were included and divided into two groups: those who underwent combined ECT and medication (31 subjects) and those who used only pharmacotherapy (68 subjects). Serum BDNF was measured in blood samples collected at admission and discharge. One hundred healthy blood donors without any psychiatric diagnosis were included as a control group.ResultsThere were no significant differences in serum BDNF levels between the combined and pharmacological groups at admission and at discharge, and no significant variation in BDNF occurred in any group during the treatment. There were no interactions between time and treatment groups nor significant time effects or treatment group effects for BDNF in the Generalized Estimating Equation Model (GEE). The control group had significantly higher serum BDNF levels in comparison with each of the treatment groups at admission and discharge (p = 0.00).ConclusionCombination of ECT with pharmacological treatment did not result in increased serum BDNF levels and did not restore levels to that of controls. |
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| Keywords: | ECT Depression BDNF Pharmacotherapy |
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