Increased BDNF levels after electroconvulsive therapy in patients with major depressive disorder: A meta-analysis study |
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| Affiliation: | 1. GGZ inGeest Specialized Mental Health Care, Department of Old Age Psychiatry, Oldenaller 1, 1081 HJ, Amsterdam, the Netherlands;2. KU Leuven, University Psychiatric Centre KU Leuven, department of Old Age Psychiatry, Leuven/Kortenberg, Belgium;3. KU Leuven, University Psychiatric Centre KU Leuven, Academic Center for ECT and Neuromodulation, Leuven/Kortenberg, Belgium;4. Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health research institute and NCA Neuroscience Amsterdam, the Netherlands;5. Amsterdam UMC, Vrije Universiteit Amsterdam, Clinical Chemistry department, the Netherlands;6. Amsterdam UMC, Vrije Universiteit Amsterdam, department of Epidemiology & Biostatistics, the Netherlands;7. Section of General Practice, Department of Public Health, University of Copenhagen, |
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| Abstract: | ObjectiveWe performed a systematic review and meta-analysis to estimate brain-derived neurotrophic factor (BDNF) level in patients with major depressive disorder (MDD) after electroconvulsive therapy (ECT).MethodA comprehensive search of the Cochrane Library, MEDLINE, LILACS, Grey literature, and EMBASE was performed for papers published from January 1990 to April 2016. The following key terms were searched: “major depressive disorder”, “unipolar depression”, “brain-derived neurotrophic factor”, and “electroconvulsive therapy”.ResultsA total of 252 citations were identified by the search strategy, and nine studies met the inclusion criteria of the meta-analysis. BDNF levels were increased among patients with MDD after ECT (P value = 0.006). The standardized mean difference was 0.56 (95% CI: 0.17–0.96). Additionally, we found significant heterogeneity between studies (I2 = 73%).ConclusionOur findings suggest a potential role of BDNF as a marker of treatment response after ECT in patients with MDD. |
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| Keywords: | BDNF Electroconvulsive therapy Major depressive disorder Meta-analysis |
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