Mode-specific physical activity and leukocyte telomere length among U.S. adults: Implications of running on cellular aging |
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| Institution: | 1. Universidade Federal do Pará – UFPA, Pós-Graduação em Genética e Biologia Molecular, Rua Augusto Corrêa 1, Belém 66075-110, PA, Brazil;2. Universidade do Estado do Pará - UEPA, Laboratório de Bioquímica do Exercício, Travessa Perebebuí 2623, Belém 66087-310, PA, Brazil;3. Universidade Brasil, Post-graduation Program in Bioengineering and in Biomedical Engineering, Rua Carolina Fonseca 235, São Paulo 08230-030, SP, Brazil;4. Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), Rua Pedro Ernesto 240, São José dos Campos 12245-520, SP, Brazil;5. Federal University of São Paulo (UNIFESP), Post-graduation Program in Sciences of Human Movement and Rehabilitation, Avenida Ana Costa 95, Santos 11060-001, SP, Brazil;6. University Anhembi Morumbi, School of Medicine, Avenida Benedito Deputado Benedito Matarazzo 4050, São José dos Campos 12230-002, SP, Brazil;1. Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan;1. Service de gériatrie, Hôpital Soignies, Rue de la station 103, 7090 Braine-le-comte, Belgium;2. Service d''hématologie, Hôpital Erasme, 808 route de Lennik, 1070 Bruxelles, Belgium;3. Service de gériatrie, Hôpital Erasme, 808 route de Lennik, 1070 Bruxelles, Belgium;4. Institute for Medical Immunology (IMI), Université Libre de Bruxelles, 8 rue Adrienne Bolland, B-6041 Charleroi, Belgium;5. CHU Saint Pierre, Université Libre de Bruxelles, rue Haute 322, 1000 Bruxelles, Belgium |
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| Abstract: | BackgroundPrevious research demonstrates that physical activity participation is associated with longer leukocyte telomere length, with shorter leukocyte telomere length being a hallmark characteristic of cellular aging. What remains under-investigated, however, is whether there is a mode-specific association of physical activity on leukocyte telomere length, which was this study's purpose.MethodsData from the 1999–2002 National Health and Nutrition Examination Survey were used (N = 6474 adults analyzed). Leukocyte telomere length was assessed using quantitative polymerase chain reaction. Physical activity was assessed via self-report, with participants classified as meeting physical activity guidelines (≥ 2000 metabolic equivalent of task-min-month) for 9 separate physical activities, including aerobics (unweighted percent meeting guidelines: 2.98%; n = 193), basketball (2.0%; n = 129), bicycling (3.71%; n = 240), dance (2.30%; n = 149), running (3.09%; n = 200), stair climbing (1.33%, n = 86), swimming (1.85%, n = 120), walking (13.53%; n = 876), and weight lifting (2.61%; n = 169).ResultsIn a single multivariable linear regression model including the independent variables of age, gender, race-ethnicity, weight status, total cholesterol, C-reactive protein, total metabolic equivalent of task-min-month of physical activity and the 9 binary meeting physical activity guideline variables, the only mode of physical activity that was significantly associated with leukocyte telomere length was meeting physical activity guidelines from running (β = 0.06; 95% CI: 0.01–0.11; P = 0.03).ConclusionRunning-specific physical activity was the only evaluated physical activity associated with leukocyte telomere length, which may provide one potential mechanism (i.e., leukocyte telomere length) through which running-based physical activity may help to prevent cardiovascular disease and premature mortality. |
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