Antidepressant use during pregnancy and risk of postpartum hemorrhage: A systematic review and meta-analysis |
| |
| Affiliation: | 1. Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, Canada;2. Department of Psychiatry, McGill University, Montréal, Québec, Canada;3. Department of Medicine, McGill University, Montréal, Québec, Canada;4. Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montréal, Québec, Canada;5. Department of Psychology, McGill University, Montréal, Québec, Canada;6. Department of Educational and Counselling Psychology, McGill University, Montréal, Québec, Canada;7. School of Nursing, McGill University, Montréal, Québec, Canada;8. Department of Oncology, McGill University, Montréal, Québec, Canada;9. Department of Public Health Sciences, Queen''s University, Kingston, Ontario, Canada;10. Harold E. Harrison Medical Library, Johns Hopkins Bayview Medical Center, Baltimore, MD, USA;11. McGill University Health Centre, Royal Victoria Hospital, Montréal, Québec, Canada;12. Health Psychology Section, Department of Health Sciences, University Medical Center Groningen, University of Groningen, The Netherlands;13. Psychological Medicine and Health Services Research, Hull York Medical School and Department of Health Sciences, University of York, York, UK;14. Public Health Department, Laval Regional Health Board, Laval, Québec, Canada;15. Women''s Health Program, University Health Network, Toronto, Ontario, Canada;p. Departments of Psychiatry, Obstetrics and Gynaecology, Family and Community Medicine, Medicine, Surgery and Anesthesia, University of Toronto, Ontario, Canada;1. Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada;2. School of Nursing, McMaster University, Hamilton, ON L8N 3Z5, Canada;3. College of Health Professions, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA;4. Faculty of Science, McMaster University, Hamilton, ON L8S 4M1, Canada;5. Department of Obstetrics & Gynecology, McMaster University, Hamilton, ON L8S 4K1, Canada;6. Division of Women''s Mental Health, Women''s College Research Institute, Toronto, ON M5G 1N8, Canada;7. Arthur Labatt Family School of Nursing, Western University, London, ON N6A 5C1, Canada;8. Diabetes Care and Research Program, Hamilton Health Sciences, Hamilton, ON L8N 3Z5, Canada;2. Black Dog Institute, Sydney, NSW, Australia |
| |
| Abstract: | Evidence about relationship between antidepressant use during pregnancy and the risk of postpartum hemorrhage (PPH) is conflicting. The aim of this meta-analysis was to systematically assess this relationship. To identify relevant studies, we conducted systematic searches in PubMed and Embase of articles published through May 2016. Random-effects models were adopted to estimate overall relative risk. In total, eight studies involving more than 40,000 PPH cases were included in our meta-analysis. After pooling the estimates, the odds for developing PPH were 1.32-fold higher (risk ratio, RR = 1.32; 95% confidence interval, CI = 1.17–1.48) in antidepressant users compared with individuals who had not taken antidepressants. In subgroup analyses, the associations still exist for women with exposure to non-SRI (RR = 1.31, 95% CI = 1.1–1.56), SRIs (RR = 1.23, 95% CI = 1.06–1.44), SSRIs (RR = 1.2, 95% CI = 1.04–1.38), and SNRIs (RR = 1.62, 95% CI = 1.41–1.85). Based on exposure window, we found an increased risk of PPH among current (RR = 1.37, 95% CI = 1.09–1.71) and recent users (RR = 1.32, 95% CI = 1.15–1.51), but not past users (RR = 1.08, 95% CI = 0.88–1.31). The findings of this meta-analysis support an increased risk of PPH in women exposure to antidepressant during late gestation. |
| |
| Keywords: | Depression Pregnant Bleed 5HT Meta-analysis |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
