Social regulation of adult neurogenesis: A comparative approach |
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Institution: | 1. Instituto de Investigaciones en Biodiversidad y Medioambiente (INIBIOMA), Universidad Nacional del Comahue – CONICET, San Carlos de Bariloche, Argentina;2. Departamento de Física Médica, Centro Atómico Bariloche, CNEA – CONICET, San Carlos de Bariloche, Argentina;3. Instituto Andino Patagónico de Tecnologías Biológicas y Geoambientales (IPATEC), Universidad Nacional del Comahue – CONICET, San Carlos de Bariloche, Argentina;4. Laboratorio de Neurociencia Molecular y Celular, Instituto de Biología Celular y Neurociencia (IBCN)-Universidad de Buenos Aires - CONICET, Argentina |
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Abstract: | The social environment sculpts the mammalian brain throughout life. Adult neurogenesis, the birth of new neurons in the mature brain, can be up- or down-regulated by various social manipulations. These include social isolation, social conflict, social status, socio-sexual interactions, and parent/offspring interactions. However, socially-mediated changes in neuron production are often species-, sex-, and/or region-specific. In order to reconcile the variability of social effects on neurogenesis, we need to consider species-specific social adaptations and other contextual variables (e.g. age, social status, reproductive status, etc.) that shift the valence of social stimuli. Using a comparative approach to understand how adult-generated neurons in turn influence social behaviors will shed light on how adult neurogenesis contributes to survival and reproduction in diverse species. |
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Keywords: | Dentate gyrus Hypothalamus Neurogenesis Parental Psychosocial stress Sex Social behavior Social isolation Social status Subventricular zone |
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