Childhood trauma,BDNF Val66Met and subclinical psychotic experiences. Attempt at replication in two independent samples |
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| Institution: | 1. Department of Psychiatry and Behavioral Science, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan;2. Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan;3. Office for Mental Health Support, the University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan;4. Department of Psychology, University of Tsukuba, Tennodai, Tsukuba, Ibaraki, 305-8572, Japan;5. Greater Manchester West Mental Health NHS Foundation Trust, Bury New Road, Prestwich, Manchester, M25 3BL, United Kingdom;6. Department of Physical and Health Education, Graduate School of Education, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan;7. Department of Health Promotion and Human Behavior, Graduate School of Medicine/School of Public Health, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan;8. School of Advanced Science, SOKENDAI (The Graduate University for Advanced Studies), Shonan Village, Hayama, Kanagawa, 240-0193, Japan;1. National Institute for Health and Welfare, Department of Health, Mental Health Unit, PO Box 30, 00271 Helsinki, Finland;2. Department of Psychology, PO Box 9, University of Helsinki, 00014 Helsinki, Finland;3. Social Insurance Institution, Research Department, PO Box 450, 00101 Helsinki, Finland;4. Department of Psychiatry, PO Box 63, University of Helsinki, 00014 Helsinki, Finland;5. Turku University Hospital and University of Turku, 20014 Turku, Finland;6. Department of Social Psychiatry, Tampere School of Public Health, 33014 Tampere, Finland;1. Department of Psychology and Human Development, UCL Institute of Education, University College London, UK;2. Department of Psychiatry, University of Oxford, UK;3. Department of Psychiatry, University of Cambridge, UK;4. Division of Psychiatry, Faculty of Brain Sciences, University College London, UK |
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| Abstract: | Childhood trauma exposure is a robust environmental risk factor for psychosis. However, not all exposed individuals develop psychotic symptoms later in life. The Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) has been suggested to moderate the psychosis-inducing effects of childhood trauma in clinical and nonclinical samples. Our study aimed to explore the interaction effect between childhood trauma and the BDNF Val66Met polymorphism on subclinical psychotic experiences (PEs). This was explored in two nonclinical independent samples: an undergraduate and technical-training school student sample (n = 808, sample 1) and a female twin sample (n = 621, sample 2). Results showed that childhood trauma was strongly associated with positive and negative PEs in nonclinical individuals. A BDNF Val66Met x childhood trauma effect on positive PEs was observed in both samples. These results were discordant in terms of risk allele: while in sample 1 Val allele carriers, especially males, were more vulnerable to the effects of childhood trauma regarding PEs, in sample 2 Met carriers presented higher PEs scores when exposed to childhood trauma, compared with Val carriers. Moreover, in sample 2, a significant interaction was also found in relation to negative PEs. Our study partially replicates previous findings and suggests that some individuals are more prone to develop PEs following childhood trauma because of a complex combination of multiple factors. Further studies including genetic, environmental and epigenetic factors may provide insights in this field. |
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| Keywords: | Childhood trauma Psychosis Psychotic experiences Gene-environment interaction Psychosis proneness |
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