The neurocircuitry involved in oxytocin modulation of methamphetamine addiction |
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| Affiliation: | 1. School of Psychology, University of Sydney, Sydney, NSW 2109, Australia;2. Department of Psychology, Macquarie University, North Ryde, NSW 2109, Australia;1. School of Psychology, University of Sydney, Sydney, NSW 2109, Australia;2. Department of Psychology, Macquarie University, North Ryde, NSW 2109, Australia;1. Departments of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90024;2. Departments of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California 90024;3. Departments of Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90024;1. School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, Surrey, UK;2. Department of Pharmacology, School of Medicine, University of Murcia, Spain;3. Institute of Medical and Biomedical Education, St George''s University of London, London SW17 0RE, UK;1. Department of Psychological and Brain Sciences, University of California at Santa Barbara, Santa Barbara, California;2. Molecular, Cellular and Developmental Biology, University of California at Santa Barbara, Santa Barbara, California;3. Neuroscience Research Institute, and Institute for Collaborative Biotechnology, University of California at Santa Barbara, Santa Barbara, California;4. Translational Neuroscience Facility, School of Medical Sciences, University of New South Wales, New South Wales, Australia;5. Behavioral Neuroscience and Methamphetamine Abuse Research Center, Oregon Health & Science University; VA Portland Health Care System, Portland, Oregon;1. National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia;2. School of Psychiatry, University of New South Wales, Sydney, Australia |
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| Abstract: | The role of oxytocin in attenuating the abuse of licit and illicit drugs, including the psychostimulant methamphetamine, has been examined with increased ferocity in recent years. This is largely driven by the potential application of oxytocin as a pharmacotherapy. However, the neural mechanisms by which oxytocin modulates methamphetamine abuse are not well understood. Recent research identified an important role for the accumbens core and subthalamic nucleus in this process, which likely involves an interaction with dopamine, glutamate, GABA, and vasopressin. In addition to providing an overview of methamphetamine, the endogenous oxytocin system, and the effects of exogenous oxytocin on drug abuse, we propose a neural circuit through which exogenous oxytocin modulates methamphetamine abuse, focusing on its interaction with neurochemicals within the accumbens core and subthalamic nucleus. A growing understanding of exogenous oxytocin effects at a neurochemical and neurobiological level will assist in its evaluation as a pharmacotherapy for drug addiction. |
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| Keywords: | Addiction Methamphetamine Nucleus accumbens core Oxytocin Subthalamic nucleus |
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