Joint effects of objectively-measured sedentary time and physical activity on all-cause mortality |
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| Institution: | 1. Physical Activity Epidemiology Laboratory, Jackson Heart Study Vanguard Center of Oxford, Department of Health, Exercise Science, and Recreation Management, The University of Mississippi, University, MS, United States;2. Kevser Ermin Applied Physiology Laboratory, Department of Health, Exercise Science, and Recreation Management, The University of Mississippi, University, MS, United States;3. Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Hospital, Baltimore, MD, United States;1. School of Sport Sciences, UiT The Arctic University of Norway, Tromsø, Norway;2. Department of Medical Informatics, Biometry and Epidemiology (IBE), Ludwig-Maximilians-Universität München, Munich, Germany;3. Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway;4. Department of Cardiology, University Hospital of North Norway, Tromsø, Norway;5. Department of Sport Medicine, Norwegian School of Sport Sciences, Oslo, Norway;6. Norwegian Institute for Public Health, Oslo, Norway;7. Department of Health and Care Sciences, UiT The Arctic University of Norway, Tromsø, Norway;8. Department of Clinical Therapeutic Services, University Hospital of Northern Norway, Tromsø, Norway;9. Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway;10. Department of Neurology, University Hospital of North Norway, Tromsø, Norway;11. Centre for Clinical Research and Education, University Hospital of North Norway Trust, Tromsø, Norway |
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| Abstract: | ObjectiveExamine the joint effects of objectively-measured sedentary time and moderate-to-vigorous physical activity (MVPA) on all-cause mortality.MethodsThe present study included data from the 2003–2006 National Health & Nutrition Examination Survey, with mortality follow-up data (via National Death Index) through 2011 (N = 5575 U.S. adults). Sedentary time (activity counts/min between 0 and 99) and MVPA (activity counts/min ≥ 2020) were objectively measured using the ActiGraph 7164 accelerometer.ResultsThe median age of the participants was 50 yrs; proportion of men was 50.2%; proportion of whites was 53.8%, 18.7% for blacks; median follow-up was 81 months; and 511 deaths occurred over the follow-up period. After adjusting for age, gender, race-ethnicity, cotinine, weight status, poverty level, C-reactive protein and comorbid illness (summed score of 0–8 chronic diseases), and for a 1 min increase in MVPA and sedentary time, both MVPA (HRadjusted = 0.98; 95% CI: 0.96–0.99; P = 0.04) and sedentary time (HRadjusted = 1.001; 95% CI: 1.0003–1.002; P = 0.008) were independently associated with all-cause mortality. Further, MVPA was associated with all-cause mortality among those with greater (above median) sedentary time (HRadjusted = 0.95; 95% CI: 0.93–0.97; P < .001). Sedentary time was not associated with all-cause mortality among those engaging in above median levels of MVPA (HRadjusted = 0.998; 95% CI: 0.996–1.001; P = .32), but sedentary time was associated with increased mortality risk among those below median levels of MVPA (HR = 1.002; 95% CI: 1.001–1.003; P < 0.001).ConclusionsSedentary time and MVPA are independently associated with all-cause mortality. Above median sedentary time levels did not negate the beneficial effects of MVPA on all-cause mortality risk. |
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