Formal thought disorder in first-episode psychosis |
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| Affiliation: | 1. Manisa Psychiatric Hospital, Manisa, Turkey;2. Department of Neuroscience, Dokuz Eylul University, Izmir, Turkey;3. Department of Psychiatry, Medical School of Dokuz Eylul University, Izmir, Turkey;1. New York State Psychiatric Institute at Columbia University, 1051 Riverside Drive, New York, NY, USA;2. Columbia University School of Social Work, New York, NY, USA;3. Brooklyn College, Department of Psychology, Brooklyn, NY, USA;4. The Graduate Center of the City University of NY (CUNY), New York, NY USA;5. Creedmoor Psychiatric Center, New York Office of Mental Health, New York, NY, USA;6. NYU Department of Psychiatry, New York, NY, USA;1. Department of Psychology, Louisiana State University, Baton Rouge, LA 70803, USA;2. Psychiatry Research Group, Department of Clinical Medicine, University of Tromsø, Norway;3. The Norwegian Centre for Integrated Care and Telemedicine (NST), University Hospital of North Norway, Tromsø, Norway;1. Department of Psychiatry, Yong-In Mental Hospital, Yongin, Republic of Korea;2. Institute of Mental Health, Hanyang University, Seoul, Republic of Korea;3. Department of Psychiatry, Hanyang University Guri Hospital, Guri, Republic of Korea;4. Department of Psychiatry, Kangwon University School of Medicine, Chuncheon, Republic of Korea;5. Department of Psychiatry, St. Andrew''s Neuropsychiatric Hospital, Icheon, Republic of Korea;6. Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea;1. University of Arizona, Tucson, AZ, USA;2. Texas Tech University Health Sciences Center, El Paso, TX, USA;3. University of California at San Diego, San Diego, CA, USA |
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| Abstract: | Formal thought disorder (FTD) is one of the fundamental symptom clusters of schizophrenia and it was found to be the strongest predictor determining conversion from first-episode acute transient psychotic disorder to schizophrenia. Our goal in the present study was to compare a first-episode psychosis (FEP) sample to a healthy control group in relation to subtypes of FTD. Fifty six patients aged between 15 and 45 years with FEP and forty five control subjects were included in the study. All the patients were under medication for less than six weeks or drug-naive. FTD was assessed using the Thought and Language Index (TLI), which is composed of impoverishment of thought and disorganization of thought subscales. FEP patients showed significantly higher scores on the items of poverty of speech, weakening of goal, perseveration, looseness, peculiar word use, peculiar sentence construction and peculiar logic compared to controls. Poverty of speech, perseveration and peculiar word use were the significant factors differentiating FEP patients from controls when controlling for years of education, family history of psychosis and drug abuse. |
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