Posture-cognitive dual-tasking: A relevant marker of depression-related psychomotor retardation. An illustration of the positive impact of repetitive transcranial magnetic stimulation in patients with major depressive disorder |
| |
| Affiliation: | 1. Laboratory “Movement, Interactions, Performance” (E.A. 4334), University of Nantes, France;2. CHU de Nantes, Service d''Addictologie et Psychiatrie de liaison, France;3. EA SPHERE 4275 Methods for Patients-centered outcomes and Health Research, University of Nantes, Nantes, France;1. Monash Alfred Psychiatry Research Centre, Monash University and The Alfred Hospital, Melbourne, Australia;2. Department of Biomedical Engineering and Computational Science (BECS), Aalto University, Espoo, Finland;1. Service de neurochirurgie, hôpital de Hautepierre, CHU de Strasbourg, 67200 Strasbourg, France;2. Service de neurochirurgie, hôpitaux civils de Colmar, 39, avenue de la Liberté, 68024 Colmar cedex, France;3. Centre de la douleur, clinique de la Toussaint, 67000 Strasbourg, France;1. Universidade da Coruña, NEUROcom (Neuroscience and Motor Control Group) and Biomedical Institute of A Coruña (INIBIC), Department of Medicine-INEF Galicia, A Coruña, Spain;2. EMG Unit, Neurology Service, Hospital Clinic, Department of Medicine, University of Barcelona, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain;3. FENNSI Group, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain;4. Centro de Estimulación Cerebral de Galicia, A Coruña, Spain;1. Department of Neuroscience-DSN, University of Padova, Via Giustiniani 2, Padua, Italy;2. Department of Neurological and Movement Sciences, University of Verona, Piazzale L.A. Scuro 10, 37134 Verona, Italy;3. Department of Neurophysiology, Foundation IRCCS San Camillo Hospital, 30126 Venice, Italy;4. Neurology Clinic, University Hospital, Strada di Fiume, 447, 34149 Trieste, Italy;5. Institute of Constructivist Psychology, Via Martiri della Libertà 13, 35137 Padua, Italy;6. National Coordination Centre for NIDA Collaborations, Via Germania 20, 37136 Verona, Italy;7. Explora—Centro di Ricerca e Analisi Statistica, Via Cà Pisani 7, Padua, Vigodarzere, Italy;8. Addiction Department, ULSS 20, Via Germania 20, 37136 Verona, Italy;1. Non Invasive Brain Stimulation Unit, Department of Behavioural and Clinical Neurology, Santa Lucia Foundation IRCCS, Rome 00179, Italy;2. Department of System Medicine, Tor Vergata University, Rome 00133, Italy;3. Stroke Unit, Tor Vergata Policlinic, Rome 00133, Italy |
| |
| Abstract: | This study examined whether postural control variables, particularly the center-of-pressure (COP) velocity-based parameters, could be a relevant hallmark of depression-related psychomotor retardation (PMR). We first aimed at investigating the interplay between the PMR scores and the COP performance in patients with major depressive disorder (MDD), as compared to age-matched healthy controls; secondly, we focused on the impact of a repetitive transcranial magnetic stimulation (rTMS) treatment on depression, PMR scores and postural performance. 16 MDD patients, and a control group of 16 healthy adults, were asked to maintain quiet standing balance during two trials with or without vision, and while backward counting (dual task). All the position and velocity-based COP variables were computed. Before and after the rTMS session (n eligible MDD = 10), we assessed the depression level with the Montgomery–Asberg Depression Rating Scale (MADRS), the PMR scores with the French Retardation Rating Scale for Depression (ERD), and postural performance. Before the treatment, significant positive partial correlations were found between the pre-ERD scores and the velocity-based COP variables, especially in the dual-task conditions (p < 0.05). In contrast, there was no significant correlation between the post-ERD scores and any postural parameter after the treatment. The MADRS and ERD scores showed a significant decrease between before and after the rTMS intervention. For the first time, the findings clearly validated the view that the assessment of postural performance - easy to envisage in clinical settings-constitutes a reliable and objective marker of PMR in MDD patients. |
| |
| Keywords: | Depression rTMS Psychomotor retardation Posture |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
