Acute respiratory illness in children with acute lymphoblastic leukemia |
| |
Authors: | MDJohn J Iacuone MB BSKY Wong MDKevin E Bove MDBeatrice C Lampkin |
| |
Institution: | 1. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio USA;2. The Children''s Hospital Research Foundation, Cincinnati, Ohio USA |
| |
Abstract: | Ten of 70 children (14%) with acute lymphoblastic leukemia developed severe interstitial pneumonitis within three weeks after induction of central nervous system prophylactic therapy. The clinical picture was characterized by fever, cough, progressive dyspnea, and hypoxemia with complete resolution in one to three weeks, except in one patient who died during the acute illness from respiratory failure. P. carinii organisms were found in the lung tissue of only one patient. The etiology of the pneumonitis in the other nine children was probably viral, acquired or activated during a period of lymphopenia and immunosuppression. The morbidity and potential mortality from the pneumonitis warrants early recognition by open lung biopsy and intensive supportive therapy. |
| |
Keywords: | Reprint address: The Children's Hospital Research Foundation Elland Ave and Bethesda Cincinnati OH 45229 |
本文献已被 ScienceDirect 等数据库收录! |
|