Effects of Motilin and Mitemcinal (GM-611) on Gastrointestinal Contractile Activity in Rhesus Monkeys In Vivo and In Vitro |
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Authors: | Kenji Yogo Ken-ichi Ozaki Hisanori Takanashi Masao Koto Zen Itoh Satoshi ōmura |
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Institution: | (1) Fuji-Gotemba Research Laboratories, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka 412-8513, Japan;(2) Gunma University, Maebashi, Gunma 371-8512, Japan;(3) The Kitasato Institute, Minato-ku, Tokyo 108-8642, Japan;(4) Targeted Disease Areas Department, Chugai Pharmaceutical Co., Ltd., 1-1 Nihonbashi-Muromachi 2-Chome, Chuo-ku, Tokyo 103-8324, Japan |
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Abstract: | Neither the presence of motilin receptors nor their action has been investigated in monkeys. The object of this study was
to determine the effects of motilin and mitemcinal (GM-611), an erythromycin derivative, on the gastrointestinal tract in
rhesus monkeys in vivo and in vitro. In in vivo investigations in conscious monkeys, both motilin and mitemcinal induced migrating
motor complex-like contractions in the interdigestive state and also accelerated gastric emptying. In in vitro investigations,
the presence of motilin receptors in the gastrointestinal tract was demonstrated by receptor binding assays. Motilin and mitemcinal
contracted isolated duodenum strips in a concentration-dependent manner. In conclusion, rhesus monkeys may be useful for studying
the physiological and pharmacological roles of the motilin agonistic mechanism because they show reactivity to motilin both
in vivo and in vitro. |
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Keywords: | Motilin Mitemcinal GM-611 Rhesus monkey Gastrointestinal motility Gastric emptying Motilin receptor |
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