308nm准分子激光治疗白癜风的疗效

目的 探讨308 nm准分子激光治疗白癜风的疗效及其不同年龄、不同部位和不同病程患者疗效的差异,以及疗效与疗程之间的关系.方法 应用临床分组比较的开放性研究方法,选择稳定期白癜风患者360例,≥14岁及<14岁者皮损各180处,给予308nm准分子激光局部照射,每周2次共10周(20次),并随访3个月.结果 ≥14岁组和<14岁组治疗总有效率分别为62.2%和63.3%,显效率分别为34.4%和44.4%,两组比较差异无统计学意义(P>0.05);不同部位皮损的疗效显示,面颈部疗效最好,躯干四肢部疗效次之,肢端关节部疗效最差,差异有统计学意义(P均<0.05);不同病程的皮损疗效亦不相同,病程越短疗效越好,适当延长疗程可提高疗效.结论 308 nm准分子激光治疗稳定期白癜风疗效好,起效快,不良反应少,患者的年龄差别对疗效的影响不明显,而皮损的部位、病程和治疗次数对疗效有一定的影响.

The treatment efficacy of 308-nm excimer laser for vitiligo

Objective To investigate the efficacy of 308-nm excimer laser for the treatment of vitiligo in patients of different ages,lesions at different body sites,and of different disease duration,as well as the relationship between the efficacy and disease duration.Methods An open study with two parallel-groups was conducted.Three hundred and sixty patients with stable vitiligo were assigned into two groups,adults(n=180) and children(n=180),and both groups were locally irradiated with 308-nm excimer laser twice a week for ten weeks(twenty times in total) and followed up for three months.Results The total effective rates and markedly improvement rates were 62.2% and 34.4%,respectively,in adult group,and 63.3% and 44.4%,respectively,in children group.No significant difference was found between the two groups in either of the two rates(both P > 0.05).The best response was observed in vitiligo patches on the face and neck,followed in decreasing order by those on the trunk or extremities and those on the acras or joints.There was significant difference in the therapeutic effect among patches at different body sites(p< 0.05).In addition,the lesions of different duration showed different responses to the treatment.It seemed that the shorter the duration of lesions was,the better the effect would be obtained,and appropriate prolongation of therapeutic time could increase the efficacy of 308-nm excimer laser.Conclusions 308-nm excimer laser is an effective modality for the treatment of stable vitiligo with rapid acting and few adverse effects.Its efficacy for vitiligo is significantly affected by location of lesions,disease duration and number of treatment,but not by the ages of patients.