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New steroids and steroid–longacting β2agonist combinations |
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| Abstract: | New, highly selective, glucocorticoid receptor agonists based on an androstane 17β-carbothioate ester scaffold are claimed. Combinations of these steroids with novel long-acting β2 agonists are also claimed. This patent defines potential replacements for fluticasone propionate and the combination of salmeterol and fluticasone propionate (Advair?, Glaxo Wellcome, Inc.). |
| Keywords: | βadrenoceptor β2 agonist asthma chronic obstructive pulmonary disease (COPD) corticosteroid GW-685698 |