Patent Evaluation: Poly(ADP-ribose)polymerase inhibitors as potential antimicrobial agents

Summary

Novelty: Substituted benzoic acids, benzamides and esters are disclosed for use against HIV. They are said to exhibit nuclear ADP-ribosyl transferase activity and are related to known inhibitors. Potential use in trypanosomiasis and cancer is also claimed.

Biology: There are no detailed biological data to support the claims. Fifteen synthetic examples are included. A typical preferred compound is 4-methylureidobenzamide.

Structure: