Patent Evaluation: Non-Natural Nucleosides Analogues as Potent Inhibitors of Herpes Virus Replication |
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Abstract: | SummaryNovelty: The synthesis and biological evaluation of novel purine or pyrimidine base substituted tetrahydrofurans is disclosed. The compounds are claimed as antiviral agents.Biology: Antiviral activity is tabulated for all the exemplified compounds against six viruses including: HSV-1, HSV-2 and VZV. For example, ID50 values of 3.8, 3.8 and 1.9 μM against HSV-1, HSV-2 and VZV, respectively, are observed for a derivative shown below.Chemistry: The synthesis of nine analogues is fully described; the preferred compounds are 3S-(3α,4β,5α)]-9-tetrahydro-4,5-bis(hydroxymethyl)-3-furanyl]-9H-purin-6-amine and3S-(3α,4β,5α)]-2-amino-1,9-dihydro-9-tetrahydro-4,5-bis(hydroxymethyl)-3-furanyl]-6H-purin-6-one. |
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