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Pfizer's dual-acting β2 agonists/muscarinic M3 antagonists |
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| Abstract: | Bifunctional aromatic compounds that contain both β2 agonist and muscarinic antagonist pharmacophores linked by a flexible lipophilic spacer are claimed. The compounds display nanomolar potency with respect to both activities and appear designed to provide a long duration of action. The compounds are claimed to be useful in the treatment of both asthma and chronic obstructive pulmonary disease. |
| Keywords: | asthma β2 agonist bronchodilator COPD M3 antagonist MABA muscarinic antagonist |