C反应蛋白对心房颤动药物复律后复发的远期预测价值

目的研究基线C反应蛋白(CRP)水平与心房颤动(简称房颤)药物复律后远期复发之间的关系。方法 71例持续性房颤患者使用胺碘酮复律,并且接受胺碘酮维持窦性节律的治疗,复律成功43例。根据基线CRP水平将复律成功的43例分为2组(0~4 mg/L组、≥4 mg/L组)。随访观察3年后,了解基线CRP水平与房颤复发间的关系。结果随访期内,有32(74.7%)例房颤复发。CRP 0~4 mg/L组,有12(12/21,57.1%)例房颤复发,CRP水平≥4 mg/L组有20例(20/22,90.9%)房颤复发,两组比较差异有显著性(P0.05)。Cox相关分析表明CRP基线水平与房颤复发相关(风险比6.09;95%可信区间3.15~12.60)。结论在预测房颤药物复律后房颤复发上,基线CRP水平可能有预测价值。

Long-term prognostic value of baseline C-reactive protein in predicting recurrence of atrial fibrillation after pharmacological cardioversion

Objective To investigate the association between CRP and long-term risk of atrial fibrillation（AF） recurrence. Methods A total of 71 patients with persistent AF were proformed cardioversion by using amiodarone, and oral amiodarone administrated to maintain sinus rhythm. According to the baseline CRP level,43 patients with successful cardio- version were divided into two groups （ group 1 ： 0 - 4 rag/L, groups 2：≥4 mg/L）. Followed up three years for understanding the relationship between the baseline CRP level and recurrence of AF. Results Thirty-two （74.4%） patients relapsed into AF during the 3-year study period, 12 patients（ 12/21,57.1% ） relapsed into AF in group 1 and 20 patients （ 20/22,90.9% ） recurrent AF in group 2. AF recurrence was significandy lower in group I than that in group 2 （ P = 0. 02）. Analysis of Cox correlation showed that the baseline ClIP levels was related with recurrence of AF（ RR 6.09,95% CI 3.15 - 12.60）. Conclusions The results suggest that baseline CRP levels before cardioversion could has a predicting value in the recurrence of AF.