降钙素原、C-反应蛋白诊断小儿中枢神经系统感染的价值

目的 探讨血清降钙素原(PCT)、C-反应蛋白(CRP)对小儿急性细菌性及病毒性脑膜炎的诊断价值.方法 选择急性细菌性脑膜炎、病毒性脑膜炎患儿各30例,应用电化学发光免疫分析对其血清PCT 和CRP水平进行测定,并与30例健康儿童(对照组)进行比较.结果 细菌性脑膜炎组血清PCT显著高于对照组和病毒性脑膜炎组(t =7.67、5.67,均P＜0.01)；细菌性脑膜炎组、病毒性脑膜炎组血清CRP均高于对照组(t =2.52、2.47,均P＜0.05),但两组间差异无统计学意义(t=1.87,P＞0.05).结论 降钙素原、CRP对急性细菌性脑膜炎及病毒性脑膜炎的鉴别诊断具有临床应用价值.

Detection and diagnositic value of serum procalciton in and C-reacti protein in children with nervous system infection

Objective To investigate the clinical value of serum procalcitonin（PCT） and C-reactive protein （CRP） piagnosis of in children with acute bacterial meningitis and virus meningitis. Methods The serum PCT and CRP levels in 30 children with acute bacterial meningitis and 30 children with virus meningitis were measured by electrochemiluminescence immune assay（ECLIA） and compared with 30 healthy children（contrd group）. Results The level of serum PCT in bacterial meningitis group was significantly higher than that in control group and viral meningitis group（ t = 7.67,5.67 ,P 〈 0.01 ）. The level of CRP in bacterial meningitis group and viral meningitis group was high- er than that in control group （ t = 2.52,2.47, P 〈 0.05 ）, but no significant difference between bacterial meningitis group and viral meningitis group（ t = 1.87,P 〉 0.05 ）. Conclusion PCT and CRP had clinical application value in the differential diagnosis of bacterial and viral meningitis.