托吡卡胺滴眼液防治青少年假性近视效果分析

目的 观察托吡卡胺滴眼液防治青少年假性近视的效果,探讨其临床价值.方法 回顾性分析68例(136只眼)青少年假性近视患者资料,观察应用托吡卡胺滴眼液的验光情况及治疗前后裸眼视力变化.结果 托吡卡胺滴眼液不同滴眼间隔(间隔1 min或间隔5min)散瞳效果差异无统计学意义(P＞0.05),且滴眼间隔不同的假性近视青少年第一次复光的屈光度检查差异无统计学意义(P＞0.05)；治疗前、治疗后1周散瞳验光裸眼远视力差异有统计学意义(x2=16.3308,P=0.000969964)；治疗1周、治疗4周散瞳光情况差异有统计学意义(x2=50.2750,P=6.98115 × 10-11).结论 0.25％托吡卡胺滴眼液间隔1 min、5 min滴眼散瞳效果满意.托吡卡胺短期内使用能够有效解除青少年假性近视的调节痉挛和调节麻痹现象,而且无明显药物不良反应,具有临床使用价值.

Clinical efficacy of tropicamide eyedrop in treatment adolescent pseudomyopia

Objective To investigate the effect of tropicamide eyedrop in the treatment adolescent pseudomyopia. Methods Tropicamide eyedrop were instilled at 68 adolescents （ 136 eyes） with pseudomyopia. Effects of mydriasis were observed and visual acuity scopes were analyzed based on ehi-square test. Results The time interval（ 1 minute or five minutes time interval） between the instillation of the two drops had no significant influence on effects of mydriasis （P 〉 0.05 ）. And the time interval between the instillation of the two drops had no significant influence on dioptoscopy（P 〉0.05 ）. There was significant difference in the visual acuity scopes before treatment and post-treatment（χ2 = 16. 3308, P = 0. 000969964 ）. There was significant difference in the visual acuity scopes in one-week treatment and four-week treatment （ χ2 = 50. 2750, P = 6. 98115 × 10-11 ）. Conclusion Instilling two drops of 0. 25% tropicamide eyedrop 1 minute or 5 minutes could achieve satisfied mydriasis effect. Short-term application of tropicamide eyedrop could relieve the spasm of adolescent pseudomyopia.