| 维拉帕米抗缺血心肌脂质过氧化与促进前列环素合成作用 |
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| 引用本文： | 李元建,邓汉武,陈修.维拉帕米抗缺血心肌脂质过氧化与促进前列环素合成作用[J].中国药理学与毒理学杂志,1988(3). |
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| 作者姓名： | 李元建 邓汉武 陈修 |
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| 作者单位： | 湖南医科大学药理教研室，湖南医科大学药理教研室，湖南医科大学药理教研室 长沙 410078，长沙 410078，长沙 410078 |
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| 摘 要： | “钙拮抗剂维拉帕米对离体大鼠心脏缺氧再给氧损伤和在体大鼠心脏缺血再灌注损伤均有预防性保护作用。维拉帕米能显著减少缺血心肌磷酸肌酸激酶释放,降低丙二醛含量和保护超氧化物歧化酶活性。在整体动物心肌缺血再灌注损伤实验,维拉帕米能显著促进缺血心肌前列环素合成。结果表明维拉帕米对心肌缺血再灌注损伤的保护作用与抗脂质过氧化有关,其促进前列环素合成作用可能与其抗心肌缺血有关。
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| 关 键 词： | 维拉帕米 心肌缺血再灌注 超氧化物歧化酶 丙二醛 前列环素 血栓素A_2 |
Prevention of lipid peroxidation and promotion of prostacyclin synthesis by verapamil in ischemic myocardium of rat |
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| LI Yuan-jian,DENG Han-wu,CHEN Xiu Dept Pharmacology,Hunan Medical University,Changsha.Prevention of lipid peroxidation and promotion of prostacyclin synthesis by verapamil in ischemic myocardium of rat[J].Chinese Journal of Pharmacology and Toxicology,1988(3). |
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| Authors: | LI Yuan-jian DENG Han-wu CHEN Xiu Dept Pharmacology Hunan Medical University Changsha |
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| Institution: | LI Yuan-jian,DENG Han-wu,CHEN Xiu Dept Pharmacology,Hunan Medical University,Changsha 410078 |
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| Abstract: | It has been well documented that calcium antagonists can protect myocardial ischemia and reperfusion injuries. In the present study, the effect of verap amil on lipid peroxidation and prostaglan din synthesis in myocardial tissue during reoxygenation of hypoxic hearts in vitro and reperfusion of infarcted hearts in. intact rat were investigated. Verapamil significantly decreased CPK release and lowered the content of malondialdchyde and protected superoxide dismutase activity of ischemic myocardium. Verapamil markedly stimulated prostacyclin synthesis of ischemic myocar-dium in vivo, measured by R1AThe results indicate that the effect of verapamil on protection on myocardium from ischemia is correlated with prevention of myocardial lipid peroxidation, and that prostacyclin may play a role in the therapeutic effect of verapamil in myocardial ischemia. |
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| Keywords: | verapamil myocardial ischemic reperfusion superoxide dismutase malondialdehyde prostacyclins throm boxane A_2 |
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