下肢深静脉血栓形成患者抗凝蛋白缺陷的临床研究

目的探讨中国人群下肢深静脉血栓形成(LDVT)患者抗凝蛋白缺陷的发生率。方法检测100例LDVT患者和100例健康成人的抗凝血酶(AT)、蛋白S(PS)、蛋白C(PC)活性及活化蛋白C抵抗性(APCR)。结果与正常对照组相比,LDVT组AT、PS、PC活性明显降低,APCR阳性率明显升高,差异有高度统计学意义(P<0.01);本组100例LDVT患者抗凝蛋白缺陷的总发生率为25%(25100),以PS缺陷的发生率最高,为13%(13100),其次是PC,为8%(8100),AT缺陷占5%(5100),APCR缺陷的发生率最小,为4%(4100)。结论先天性或获得性抗凝蛋白缺陷是中国人群LDVT发病和复发的重要机制之一,因此有必要对LDVT病人进行抗凝蛋白水平的筛选。

Deficiencies of anticoagulant proteins in patients with deep vein thrombosis in lower Limb

Objective To investigate the incidence of anticoagulant proteins deficiency in Chinese patients with deep vein thrombosis in lower limb (LDVT). Methods Molecular markers of anticoagulant proteins were assayed in 100 patients with LDVT and 100 normal controls.Parameters include:the activity of antithrombin (AT),protein C (PC),protein S (PS) and the incidence of activated PC resistance (APCR). Results Between the LDVT group and normal group,There were significant differences in the activity of AT,PC,PS and APCR (P<0.01);Of all patients 25% (25/100) were found to be abnormal.These consisted of 13% (13/100) PS deficiencies,8% (8/100) PC deficiencies,5% (5/100) AT deficiencies and 4% (4/100) APCR deficiencies. Conclusion The results of this study suggest that the anticoagulation protein deficiencies be frequent in Chinese LDVT patients (both congenital and acquired).It suggests that the etiology of thrombophilia may be different between Chinese and Western.