Polymorphism of Qa and Tla loci of the mouse |
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Authors: | SNEH TEWARSON ZOFIA ZALESKA-RUTCZYNSKA FELIPE FIGUEROA JAN KLEIN |
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Institution: | Max-Planck-Institut für Biologie, Abteilung Immungenetik, Tubingen, Federal Republic of Germany |
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Abstract: | Congenic lines carrying H-2 haplotypes derived from wild mice were typed serologically with polyclonal and monoclonal antibodies specific for Tla, Qa-1, and Qa-2 antigens. The typing revealed the presence of a minimum of five Tla, four Qa-1 , and three Qa-2 alleles in the 32 lines. Two new Tla , two new Qa-1 , and one new Qa-2 alleles could be described. This polymorphism of Tla and Qa loci is lower than that detected at the K and D loci in the same lines. The serological typing for Qa-2 antigens correlates remarkably well with previously published results of typing with cytolytic T lymphocytes. This correlation supports the identity of loci detected by the two methods. |
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