| 金属基质蛋白酶在月经发生中的作用 |
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| 引用本文： | 徐祥波,刘书言,王乾兴,等.金属基质蛋白酶在月经发生中的作用[J].遵义医学院学报,2014(1):119-124. |
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| 作者姓名： | 徐祥波 刘书言 王乾兴 等 |
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| 作者单位： | [1]国家人口计生委科学技术研究所,北京100081 [2]广西医科大学,广西南宁530021 [3]遵义医学院,贵州遵义563099 |
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| 基金项目： | 国家自然科学基金项目（NO：30901608）;国家科技支撑计划课题（NO：2012BAl32805）. |
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| 摘 要： | 子宫内膜在精确的雌激素和孕激素的作用下，经历了增殖，分化以及在分泌晚期孕酮撤退情况下的子宫内膜周期性的崩解、脱落以及其后的再生修复过程。子宫内膜的快速崩解脱落现象是月经发生的显著特征。孕酮撤退是引发月经发生的始动因子，金属基质蛋白酶则是最终作用因子。金属基质蛋白酶（MMP）为水解酶，其家族成员众多。将对金属基质蛋白酶结构种类、剪切与活化、调节以及其在月经发生中灵长类和小鼠月经样模型中子宫内膜中的定位、表达与酶活进行阐述。
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| 关 键 词： | 金属基质蛋白酶 月经 胞外基质 |
The role of matrix metalloproteinase in menstruation |
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| Xu Xiangbo,Liu Shuyan,Wang Qianxing,Chen Xihua,Zhang Shucheng,He Bin,Wang Jiedong.The role of matrix metalloproteinase in menstruation[J].Acta Academiae Medicine Zunyi,2014(1):119-124. |
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| Authors: | Xu Xiangbo Liu Shuyan Wang Qianxing Chen Xihua Zhang Shucheng He Bin Wang Jiedong |
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| Institution: | 1. Reproductive Physiology Laboratory, National Research Institute for Family Planning, Beijing 100081 ,China;2. Guangxi Medical University, Nanning Guangxi 530021, China; 3. Zunyi Medical University, Zunyi Guizhou 563099, China) |
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| Abstract: | Endometrium undergoes proliferation, differentiation, breakdown, shedding and regeneration. This is mediated by progesterone withdrawal under the finely regulation of estradiol and progesterone. The quick breakdown and shedding is the unique character of menstruation. Progesterone withdrawal is the initiation factor, however, matrix metalloproteinase （MMP） is the final factor of endometrial shedding. MMP is hydrolytic enzyme and has many members. In the paper, the MMPs in the structure, spliceosome and activation, regulation and the location, expression and enzyme activity in primate and mouse menstrual -like model were clarified. |
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| Keywords: | matrix metalloproteinase menstruation extracellular matrix |
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