| 载脂蛋白E基因多态性与阿尔茨默病的关系探讨 |
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| 引用本文： | 陈柏铭,刘利东,陈盛强,燕启江. 载脂蛋白E基因多态性与阿尔茨默病的关系探讨[J]. 广州医学院学报, 2001, 29(1): 5-7 |
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| 作者姓名： | 陈柏铭 刘利东 陈盛强 燕启江 |
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| 作者单位： | 1. 广州医学院第一附属医院检验科,
2. 广州医学院神经研究所 |
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| 摘 要： | 目的 :探讨阿尔茨默病 (AD)患者的载脂蛋白E(ApoE)基因的分布 ,分析它们的相互关系。方法 :利用聚合酶链式反应 -限制性片段长度多态性 (PCR RFLP)技术对AD患者和相应健康对照的ApoE基因进行分型 ,从而进行AD与ApoE等位基因多态性的关联分析。结果 :AD病人ApoE等位基因ε4 占 2 0 .74% ,明显高于正常人对照组的 7.6 4% ,而ε3 则占 6 4.6 3% ,低于正常人对照组的 84.12 % ,均有极显著性差异 (P <0 .0 1)。结论 :ApoE等位基因中 ,ε4 可能为AD的易感因子 ,而ε3 则为保护因子。
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| 关 键 词： | 载脂蛋白E 阿尔茨海默病 基因多态性 聚合酶链反应－限制性片段长度多态性 PCR－RFLP |
| 文章编号： | 1008-1836(2001)01-0005-03 |
| 修稿时间： | 2000-09-08 |
Study on the Relationship between Apolipoprotein E Gene Polymorphism and the Alzheimer Desease |
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| CHEN Bo ming ,LIU Li dong ,CHEN Sheng qiang ,et al. Study on the Relationship between Apolipoprotein E Gene Polymorphism and the Alzheimer Desease[J]. Academic Journal of Guangzhou Medical College, 2001, 29(1): 5-7 |
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| Authors: | CHEN Bo ming LIU Li dong CHEN Sheng qiang et al |
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| Affiliation: | CHEN Bo ming 1,LIU Li dong 1,CHEN Sheng qiang 2,et al |
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| Abstract: | To study the distribution of ApoE gene in patients with Alzheimer desease (AD) and the relationship between them. Method: ApoE genotypes were determined by PCR-RFLP technique,and the correlation between ApoE allele polymorphism and AD was analyzed. Results: ApoE ε4 allele in patients with AD was 20.74%,significantly higher than that in the control group(7.64%), and ε3 allele in patients with AD was 64.63%,significantly lower than that in the control group (84.12%). Conclusion: The ApoE allele ε4 may be a genetic susceptible factor to AD,and ε3 allele be a protection factor. |
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| Keywords: | apolipoprotein E alzheimer disease gene polymorphism PCR RFLP |
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