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ANTIANAPHYLACTIC PROPERTIES OF EUGENOL |
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| Authors: | HYUNG-MIN KIM EUN-HEE LEE CHANG-YOUNG KIM JONG-GAB CHUNG SANG-HYUN KIM$L JONG-PIL LIM$L TAE-YONG SHIN$L |
| Affiliation: | aDepartment of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea, 570-749, Wonkwang Health College, Iksan, Chonbuk, South Korea, 570-750, Woosuk University, Wanju, Chonbuk, South Korea, 565-701;bWonkwang University, Iksan, Chonbuk, South Korea, 570-749, Department of Health and Hygiene, Wonkwang Health College, Iksan, Chonbuk, South Korea, 570-750, Woosuk University, Wanju, Chonbuk, South Korea, 565-701;cWonkwang University, Iksan, Chonbuk, South Korea, 570-749, Wonkwang Health College, Iksan, Chonbuk, South Korea, 570-750, College of Pharmacy, Woosuk University, Wanju, Chonbuk, South Korea, 565-701 |
| Abstract: | The effects of eugenol, a major component of clove, on anaphylaxis were evaluated in rats. Eugenol inhibited compound 48/80-induced systemic anaphylaxis 100% with a dose of 10 μg g−1body weight (BW). While serum levels of histamine were markedly elevated after compound 48/80 injection in all groups of rats, rats injected with eugenol showed a significant reduction in serum histamine levels. Eugenol also inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. Eugenol dose-dependently inhibited histamine release from the rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. The morphological examination clearly showed that eugenol prevented the anaphylactic degranulation of RPMC. Moreover, Eugenol (10 μg ml−1) had a significant inhibitory effect on anti-DNP IgE-induced tumor necrosis factor-α production. These results suggest that eugenol has antianaphylactic properties by preventing mast cell degranulation |
| Keywords: | eugenol anaphylaxis histamine mast cells tumor necrosis factor-alpha |
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