丹参氮酮助渗液对瘢痕治疗作用的探讨

目的　观察 5 %丹参氮酮助渗液对瘢痕的治疗效果并探讨其作用机理。方法　进行离体大鼠皮肤、活体及离体人皮肤对 5 %丹参氮酮助渗液的通透效果测定。并将应用硅膜弹力布贴膏治疗的 30 1例增生性瘢痕患者分成治疗组和对照组 ,治疗组使用含 5 %丹参氮酮助渗液的布贴膏 ,对照组则不含 ,对两组进行临床疗效观察比较。结果　离体大鼠皮肤通透试验经Poisson级数差别检验 ,差异有非常显著性意义 (χ2 =84 6 32 98,P <0 0 1) ;活体及离体人皮肤的通透效果测定 ,差异有非常显著性意义 (χ2 =15 9,P <0 0 1) ,说明 5 %丹参氮酮助渗液透皮效果良好 ;临床观察治疗组总有效率为 91 4 % ,对照组总有效率为 71 3% ,治疗组明显优于对照组。结论　 5 %丹参氮酮助渗液可以渗入皮肤 ,能显著降低皮肤电阻值 ,增加皮肤通透性 ,与硅膜弹力布贴膏合用对瘢痕有着良好的治疗效果。

Evaluation of a compound with Dan-shen root and azone for scar treatment

Objective To evaluate the effect of the compound of Dan-shen root and azone for scar treatment. Methods The rat skin in vitro and the human skin in vitro and vivo were separately examined their permeability of the mixture of the Dan-shen root and azone. The 301 patients with hypertrophic scar were randomly divided into two groups: one treated with elastic cloth paste (including silicone)contained in Dan-shen root with azone,and the another treated with only elastic cloth paste(including silicone). Results The permeability of Dan-shen root with azone,passing through the rat skin in vitro and the human skin in vitro and vivo was significantly higher than both the distilled water and the normal saline ( P <0.05). In the clinical study for treatment of the hypertrophic scars,the efficient rate of the group with the Dan-shen root with azone was significantly higher than the control ( 91.4% vs. 71.3%) ( P <0.01). Conclusion The Dan-shen root with azone could be easier to permeate the skin and more effective to treat the hypertrophic scar. ;