阳离子脂质体基因载体的研究进展

肿瘤基因治疗的最大挑战之一是研制安全有效的基因转染载体。基因治疗载体一般分为病毒性载体和非病毒性载体。由于病毒型载体存在安全性问题,目前非病毒性载体的研究越来越受到人们的重视。脂质体作为常用的非病毒性载体容易制备,安全性高,但亦存在质控要求高,体内基因导入效率较低,且无靶向性,使得其应用受到限制。pH敏脂质体、阳离子脂质体等大大提高了脂质体的转运效率,也为非病毒载体在临床上的应用开辟了广阔的前景,本文就阳离子脂质体作为基因载体的研究予以综述。

Research and Development of Cationic Liposome as Gene Carriers

One of the most important challenges of tumor gene therapy is to develop safe and effective gene transfection Carders. Gene transiecfion carriers can be classifmd as virus cartier and non-virus cartier. More and more researches focus on non-virus carrier due to absence of safety of virus carrier, Liposome is a kind of conventional non-virus carrier with easy preparation and high security,but it has the shortage of demand of high quality control, low transfection efficiency, pH-sensitive Liposome and cationic liposeme have largely improved the transfection efficiency and have opened up wide perspective for non-virus carrier in clinical application. This article reviewed the research of cationic liposeme as gene carders.