Crystal structures of the even and odd bolaform amino acid derivatives (11-N-[benzyloxycarbonyl-L-alanyl] aminoundecanoyl)-L-alanyl benzyl ester and (12-N-[benzyloxycarbonyl-L-alanyl]aminododecanoyl)-L-alanyl benzyl ester

Reaction of two α,ω-aminocarboxylic acids with N- and C-protected alanine leads to bolaform compounds with two secondary amide groups on one end and one such group at the other end. Unsymmetric sheet-like structures are formed in the crystals. (11-N-[Benzyloxycarbonyl-L-alanyl]aminoundecanoyl)-L-alanyl benzyl ester (1) and (12-N-[benzyloxycarbonyl-L-alanyl]aminododecanoyl)-L-anyl benzyl ester (2) form triclinic crystals (spacegroup P1, No.1) with a= 4.917, b= 5.614, c= 29.02 Å, α= 88.40, β= 93.50, γ= 100.21°, Z=1 (1) and a= 4.954, b= 5.613, c= 30.23 Å, α= 93.44, β= 90.07, γ= 104.15°, Z=1 (2). The crystal structures were solved via direct methods and refined to R= 0.040 (1) and 0,078 (2) from 2441 and 2125 reflections. © Munksgaard 1997.