| 东莨菪碱与氯丙嗪合用对小鼠学习记忆的影响 |
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| 引用本文： | 杨解人!药理学教研室,丁伯平!药理学教研室,陈国祥!药理学教研室,张良华!药理学教研室,宋运瑛!药理学教研室,孙瑞元!药理学教研室.东莨菪碱与氯丙嗪合用对小鼠学习记忆的影响[J].皖南医学院学报,2000(1). |
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| 作者姓名： | 杨解人!药理学教研室 丁伯平!药理学教研室 陈国祥!药理学教研室 张良华!药理学教研室 宋运瑛!药理学教研室 孙瑞元!药理学教研室 |
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| 作者单位： | Dept of Pharmacology，Wannan Medical College，Wuhu 241001 |
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| 摘 要： | 用小鼠跳台法 ,观察氯丙嗪与东莨菪碱合用对小鼠学习记忆的影响。结果表明 :东莨菪碱和氯丙嗪 (0 15 5±6 .475 )mg/kg及 (0 .46 6± 19.43)mg/kg静注 ,对小鼠学习成绩、记忆获得、巩固和记忆再现均有影响 ,但停药 2 4h和48h后所测验各项指标均与生理盐水对照组无明显差异。
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| 关 键 词： | 东莨菪碱 氯丙嗪 学习 记忆 跳台法 |
Effect of Scopolamine and Chlorpromazine on Learning and Memory in Mice |
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| Yang Jieren,Ding Boping,Chen Guoxiang,et al.Effect of Scopolamine and Chlorpromazine on Learning and Memory in Mice[J].Acta Academiae Medicinae Wannan,2000(1). |
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| Authors: | Yang Jieren Ding Boping Chen Guoxiang |
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| Abstract: | The effect of Scopolamine (Sco) and Chlorpromazine(Chl)on learning and memory of mice was investigated by using step-down test. The results indicated that Sco and Chl(0.155±6.475mg/kg,0.466+19.43/mg/kg,iv)had an influence on memory acquisition, memory consolidation and memory retrieval.But 24h or 48h after withdrawal of the drugs, all abnormal indexes were restored. There were no significant changes in the two dosage groups compared with the normal control group. |
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| Keywords: | scopolamine chlorpromazine learning memory step-down test |
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