茶多酚对大鼠长期毒性实验

以茶多酚 35 0、70 0、140 0mg/ (kg·d) ,给大鼠连续口服 180d。观察用药期间毒性反应及停药 14d期间恢复情况。茶多酚高剂量可轻度抑制大鼠体重的增长 ,引起部分大鼠肝和肾的损害 ,甚至个别动物出现死亡 ;中剂量组大鼠体重增长减慢 ,且表现有毛色灰暗 ,精神萎糜 ,停药后均可减轻或消失 ;低剂量组动物未见毒性反应。结果提示茶多酚对大鼠是无毒的 ,剂量为 35 0mg/ (kg·d)。

Test of Chronic Toxicity of TPP in Rats

After being given po tea polyphenols(TT)350,700,1400mg/(kg·d\+\{-1\})for 180 days, rats were observed in the toxicity of TPP. The results showed that giving TPP 1400mg/(kg·d\+\{-1\}) for 180 days could inhabit the weight of growth of rats, lead to the damaged liver and kidneys and in case of a few rats , even to death.The chronic toxicity was not found in doses of TPP 350 and 700mg/(kg·d)for 180 days , which suggested that those two dosages had no toxic effect on rats.