初诊2型糖尿病患者微血管病变的患病率及相关危险因素分析

目的明确北京地区初诊2型糖尿病患者微血管病变(外周神经病变,视网膜病变,糖尿病肾病)的患病率,并对其相关危险因素进行分析。方法对402例新诊断的2型糖尿病患者进行眼底荧光造影和尿微量白蛋白、神经传导速度及相关指标测定,计算微血管病变的患病率,并对相关因素行Logistic回归分析。结果(1)初诊糖尿病的患者中糖尿病肾病的患病率为16.1%;糖尿病视网膜病变的患病率为18.7%;糖尿病神经病变的患病率为37.3%。(2)收缩压和糖化血红蛋白为糖尿病视网膜病变的独立危险因素。(3)年龄、收缩压、舒张压、空腹血糖、餐后两小时血糖及糖化血红蛋白为糖尿病外周神经病变的独立危险因素。(4)初诊2型糖尿病女性糖尿病视网膜病变、糖尿病肾病的患病率高于男性。结论北京地区初诊2型糖尿病微血管病变占一定比例,微血管病变的患病率存在性别差异,控制血压、血糖有利于改善糖尿病微血管病变。

The prevalence of microvascular compliations and Relative Factors in newly diagnosed Type 2 Diabetic Patients

Objective To determine the prevalence of microvascular compliations in newly diagnosied type 2 diabetic subject and find the risk factor.Methods 402 subjects were iocluded in the study.Plasma glucose,lipid profiles,insulin and blood pressure were measured, and diabetic retinopathy,neuropathy and nephropathy were detected by fundus fluorescein angiography,electromyography and urinary albumin protein exerection rate.Results (1)The prevalence of diabetic nephropathy was 16.1%.Retinopathy was detected in 18.7% of the patients.Among the newly diagnosied diabetics neuropathy had 37.3%.(2)Multivariate logistic regression analysis showed that systolic blood pressure and glycosylated haemoglobin value were associated with retinopathy.(3)Age,systolic blood pressure,diastolic blood pressure,glycosylated haemoglobin value,fasting plasma glucose and 2-hour plasma glucose were risk for neuropathy.(4)There is gender difference of microvascular complications in newly diagnosed type 2 diabetic patients.Conclusions A certain percentage of complications exists in newly diagnosied type 2 diabetes.Controling hypertention and glucose can improve diabetic microvacular complications.